常勤スタッフ

天谷 雅行

Masayuki Amagai

慶應義塾大学常任理事(研究担当)
慶應義塾大学教授(医学部皮膚科学)
理化学研究所 生命医科学研究センターチームリーダー(非常勤)

略歴/専門/資格

略歴

1985年
慶應義塾大学医学部卒業
1989年
慶應義塾大学大学院医学研究科博士課程修了
1989年
北里研究所病院皮膚科
1989年
米国国立衛生研究所国立癌研究所皮膚科(Dermatology Branch, NCI, NIH)
1992年
東京電力病院皮膚科
1996年
愛媛大学助手(医学部皮膚科学)
1996年
慶應義塾大学専任講師(医学部皮膚科学)
2005年
慶應義塾大学教授(医学部皮膚科学)
2007年
慶應義塾大学病院副病院長(2013年9月まで)
2013年
理化学研究所 生命医科学研究センターチームリーダー(非常勤)
2013年
慶應義塾大学医学部学部長補佐(2017年9月まで)
2017年
慶應義塾大学医学部長(2021年7月まで)
2021年
慶應義塾大学常任理事(研究担当)
現在に至る

専門

臨床領域
皮膚全般、自己免疫性水疱症、アレルギー性疾患、皮膚感染症
研究領域
皮膚免疫学、細胞生物学、分子生物学

受賞歴

1991年
皆見賞(日本皮膚科学会)
2000年
JSID賞(日本研究皮膚科学会)
2002年
Alfred Marchionini Forschungspreis 2002 (20th World Congress of Dermatology)
2005年
CE.R.I.E.S. Research Award
2006年
日本学術振興会賞
2006年
日本免疫学会賞
2010年
Honorary membership of the Austrian Society of Dermatology and Venerology
2012年
ベルツ賞(一等賞)
2015年
Honorary membership of the European Society for Dermatological Research
2015年
Honorary membership of the German Dermatology Society
2016年
International honorary member of American Dermatological Association
2016年
International Member of the National Academy of Medicine, USA
2018年
日本学術会議会員(24-25期)
2019年
Honorary membership of the Society for Investigative Dermatology

記念講演

2002年
Morris H. Samitz Lecture at University of Pennsylvania, Department of Dermatology
2003年
William Montagna Lecture at the Society for Investigative Dermatology
2015年
Arthur Rook Oration at British Association of Dermatologists
2017年
Rudi Cormane Lecture at the European Society for Dermatological Research
2018年
Sven Hellerström Lecture at Karolinska Institutet, Sweden
2018年
Kung Sun Oh Memorial Lecture at Yonsei University, Korea
2020年
Yau-Chin Lu Lecture at Taiwanese Dermatological Association
2021年
Aaron Lerner Discovery Lecture at Yale University

学会活動

日本皮膚科学会(理事 2011-,副理事長 2016-2018, 理事長 2018-)

日本研究皮膚科学会
(若手理事1999-2002, 理事2003-2010, 事務局長 2010-2011, 理事長2011-2014)

日本免疫学会 (評議員2008-)

日本炎症・再生医学会(評議員2010-、理事2013-)

International Investigative Dermatology (Founding Board of Director 2014-, Secretary General 2019-)

Society for Investigative Dermatology

European Society for Dermatological Research

American Academy of Dermatology

雑誌編集委員等

The Journal of Clinical Investigation (Consulting Editor, 2007- )

Fitzpatrick’s Dermatology in General Medicine 9th edition (Editor, 2014- )

The Journal of Investigative Dermatology (Section Editor, 2002-2017)

The Journal of Dermatological Science (Editorial Board, 2001- )

British Journal of Dermatology (Editorial Advisory Board, 2001- )

The Journal of American Academy of Dermatology (Editorial Board, 1998- 2008)

Experimental Dermatology (Editorial Board, 2003-2014)

Der Hautarzt (Editorial Board, 2007- )

Faculty 1000 Medicine (Section head 2005- )

臨床皮膚科(編集委員2006-2010)

研究成果/論文

代表的な論文

  • Amagai M, Klaus-Kovtun V, Stanley JR. Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion. Cell 67 (5): 869-877, 1991.

  • Amagai M, Karpati S, Prussick R, Klaus-Kovtun V, Stanley JR. Autoantibodies against the amino-terminal cadherin-like binding domain of pemphigus vulgaris antigen are pathogenic. J Clin Invest 90 (3): 919-926, 1992.

  • Tang A, Amagai M, Granger LG, Stanley JR, Udey MC: Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin. Nature 361: 82-85, 1993

  • Amagai M, Hashimoto T, Shimizu N, Nishikawa T. Absorption of pathogenic autoantibodies by the extracellular domain of pemphigus vulgaris antigen (Dsg3) produced by baculovirus. J Clin Invest 94 (1): 59-67, 1994.

  • Ishii K, Amagai M, Hall RP, Hashimoto T, Takayanagi A, Gamou S, Shimizu N, Nishikawa T: Characterization of autoantibodies in pemphigus using antigen-specific ELISAs with baculovirus expressed recombinant desmogleins. J Immunol 159: 2010-2017, 1997

  • Amagai M, Nishikawa T, Nousari HC, Anhalt GJ, Hashimoto T. Antibodies against desmoglein 3 (pemphigus vulgaris antigen) are present in sera from patients with paraneoplastic pemphigus and cause acantholysis in vivo in neonatal mice. J Clin Invest 102 (4): 775-782, 1998.

  • Amagai M, Matsuyoshi N, Wang ZH, Andl C, Stanley JR. Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1. Nat Med 6 (11): 1275-1277, 2000.

  • Amagai M, Tsunoda K, Suzuki H, Nishifuji K, Koyasu S, Nishikawa T. Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus. J Clin Invest 105 (5): 625-631, 2000.

  • Nagasaka T, Nishifuji K, Ota T, Whittock NV, Amagai M. Defining the pathogenic involvement of desmoglein 4 in pemphigus and staphylococcal scalded skin syndrome. J Clin Invest 114 (10): 1484-1492, 2004.

  • Stanley JR, Amagai M. Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome. N Engl J Med 355 (17): 1800-1810, 2006.

  • Fallon PG, Sasaki T, Sandilands A, Campbell LE, Saunders SP, Mangan NE, Callanan JJ, Kawasaki H, Shiohama A, Kubo A, Sundberg JP, Presland RB, Fleckman P, Shimizu N, Kudoh J, Irvine AD, Amagai M, McLean WH. A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming. Nat Genet 41 (5): 602-608, 2009.

  • Kubo A, Nagao K, Yokouchi M, Sasaki H, Amagai M. External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers. J Exp Med 206 (13): 2937-2946, 2009.

  • Takahashi H, Kouno M, Nagao K, Wada N, Hata T, Nishimoto S, Iwakura Y, Yoshimura A, Yamada T, Kuwana M, Fujii H, Koyasu S, Amagai M. Desmoglein 3-specific CD4+ T cells induce pemphigus vulgaris and interface dermatitis in mice. J Clin Invest 121 (9): 3677-3688, 2011.

  • Kawasaki H, Nagao K, Kubo A, Hata T, Shimizu A, Mizuno H, Yamada T, Amagai M. Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice. J Allergy Clin Immunol 129 (6): 1538-1546, 2012.

  • Kubo A, Nagao K, Amagai M. Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases. J Clin Invest 122 (2): 440-447, 2012.

  • Nagao K, Kobayashi T, Moro K, Ohyama M, Adachi T, Kitashima DY, Ueha S, Horiuchi K, Tanizaki H, Kabashima K, Kubo A, Cho YH, Clausen BE, Matsushima K, Suematsu M, Furtado GC, Lira SA, Farber JM, Udey MC, Amagai M. Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin. Nat Immunol 13 (8): 744-752, 2012.

  • Hata T, Nishimoto S, Nagao K, Takahashi H, Yoshida K, Ohyama M, Yamada T, Asano K, Amagai M. Ectopic expression of epidermal antigens renders the lung a target organ in paraneoplastic pemphigus. J Immunol 191 (1): 83-90, 2013.

  • Sasaki T, Shiohama A, Kubo A, Kawasaki H, Ishida-Yamamoto A, Yamada T, Hachiya T, Shimizu A, Okano H, Kudoh J, Amagai M. A homozygous nonsense mutation in the gene for Tmem79, a component for the lamellar granule secretory system, produces spontaneous eczema in an experimental model of atopic dermatitis. J Allergy Clin Immunol 132 (5): 1111-1120, 2013

  • Kubo A, Shiohama A, Sasaki T, Nakabayashi K, Kawasaki H, Atsugi T, Sato S, Shimizu A, Mikami S, Tanizaki H, Uchiyama M, Maeda T, Ito T, Sakabe J, Heike T, Okuyama T, Kosak iR, Kosaki K, Kudoh J, Hata K, Umezawa A, Tokura Y, Ishiko A, Niizeki H, Kabashima K, Mitsuhashi Y, Amagai M. Mutations in SERPINB7, Encoding a Member of the Serine Protease Inhibitor Superfamily, Cause Nagashima-type Palmoplantar Keratosis. Am J Hum Genet 93 (5): 945-956, 2013

  • Yoshida K, Kubo A, Fujita H, Yokouchi M, Ishii K, Kawasaki H, Nomura T, Shimizu H, Kouyama K, Ebihara T, Nagao K, Amagai M: Distinct behavior of human Langerhans cells and inflammatory dendritic epidermal cells at tight junctions in atopic dermatitis. J Allergy Clin Immunol 134 (4), 856-864, 2014.

  • Kobayashi T, Glatz M, Horiuchi K, Kawasaki H, Akiyama H, Kaplan DH, Kong HH, Amagai M, Nagao K: Dysbiosis and Staphyloccus aureus Colonization Drives Inflammation in Atopic Dermatitis. Immunity, 42 (4), 756-766, 2015.

  • Adachi T, Kobayashi T, Sugihara E, Yamada T, Ikuta K, Pittaluga S, Saya H, Amagai M, Nagao K: Hair follicle-derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma. Nat Med, 21 (11), 1272-1279, 2015.

  • Amagai M. Cracking the code of skin inflammation with CD1a. Nat Immunol. 17(10), 1133-1134, 2016.

  • Amagai M. Modulating immunity to treat autoimmune disease. New Eng J Med, 375(15) 1487-1489, 2016.

  • Yokouchi M, Atsugi T, Logtestijn MV, Tanaka RJ, Kajimura M, Suematsu M, Furuse M, Amagai M, Kubo A. Epidermal cell turnover across tight junctions based on Kelvin’s tetrakaidecahedron cell shape. eLife 5 e19593, 2016.

  • Someya T and Amagai M. Toward a new generation of smart skins. Nat Biotechnol 37(4), 382-388, 2019.

  • Matsui T, Kadono-Maekubo N, Suzuki Y, Furuichi Y, Shiraga K, Sasaki H, Ishida A, Takahashi S, Okada T, Toyooka K, Sharif J, Abe T, Kiyonari H, Tominaga M, Miyawaki A, and Amagai M. A unique mode of keratinocyte death requires intracellular acidification Proc Natl Acad Sci 118(17) e2020722118; https://doi.org/10.1073/pnas.2020722118, 2021.

  • Iriki H, Takahashi H, Wada N, Nomura H, Mukai M, Kamata A, Ito H, Yamagami J, Matsui T, Kurebayashi Y, Mise-Omata S, Nishimasu H, Nureki O, Yoshimura A, Hori S, Amagai M. Peripheral tolerance by Treg via constraining OX40 signal in autoreactive T cells against desmoglein 3, a target antigen in pemphigus. Proc Natl Acad Sci 118 (49): 1-12,  doi: 10.1073/pnas.2026763118,  2021.

  • Takahashi H, Nomura H, Iriki H, Kubo A, Isami K, Mikami Y, Mukai M, Sasaki T, Yamagami J, Kudoh J, Ito H, Kamata A, Kurebayashi Y, Yoshida H, Yoshimura A, Sun HW, Suematsu M, O’Shea JJ, Kanno Y, Amagai M. Cholesterol 25-hydroxylase is a metabolic switch to constrain T cell-mediated inflammation in the skin. Sci Immunol 6 (64):  doi: 10.1126/sciimmunol.abb6444,  2021.