研究テーマ

Strategy to unveil and overcome autoimmune diseases

In this study, we analyzed pemphigus and a pemphigus mouse model as an autoimmune prototype in which desmoglein 3 was known as the target autoantigen. We aimed to develop antigen-selective immunosuppressive therapies with fewer side effects by clarifying autoimmune and immune tolerance mechanisms as universal immune phenomena through analysis of the disease and its mouse model.