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代表的な論文

2014

Yoshida K, Kubo A, Fujita H, Yokouchi M, Ishii K, Kawasaki H, Nomura T, Shimizu H, Kouyama K, Ebihara T, Nagao K, Amagai M
Distinct behavior of human Langerhans cells and inflammatory dendritic epidermal cells at tight junctions in patients with atopic dermatitis
J Allergy Clin Immunol, 134 (4): 856-864, 2014.10.Pubmed

 

2013

Kubo A, Shiohama A, Sasaki T, Nakabayashi K, Kawasaki H, Atsugi T, Sato S, Shimizu A, Mikami S, Tanizaki H, Uchiyama M, Maeda T, Ito T, Sakabe J, Heike T, Okuyama T, Kosaki R, Kosaki K, Kudoh J, Hata K, Umezawa A, Tokura Y, Ishiko A, Niizeki H, Kabashima K, Mitsuhashi Y, Amagai M
Mutations in SERPINB7, encoding a member of the serine protease inhibitor superfamily, cause Nagashima-type palmoplantar keratosis
Am J Hum Genet, 93 (5): 945-956, 2013.11.Pubmed

Sasaki T, Shiohama A, Kubo A, Kawasaki H, Ishida-Yamamoto A, Yamada T, Hachiya T, Shimizu A, Okano H, Kudoh J, Amagai M
A homozygous nonsense mutation in the gene for Tmem79, a component for the lamellar granule secretory system, produces spontaneous eczema in an experimental model of atopic dermatitis
J Allergy Clin Immunol, 132 (5): 1111-1120.e1114, 2013.11.Pubmed

Nishimoto S, Kotani H, Tsuruta S, Shimizu N, Ito M, Shichita T, Morita R, Takahashi H, Amagai M, Yoshimura A
Th17 Cells Carrying TCR Recognizing Epidermal Autoantigen Induce Psoriasis-like Skin Inflammation
J Immunol, 191 (6): 3065-3072, 2013.09. Pubmed

Hata T, Nishimoto S, Nagao K, Takahashi H, Yoshida K, Ohyama M, Yamada T, Asano K, Amagai M
Ectopic expression of epidermal antigens renders the lung a target organ in paraneoplastic pemphigus
J Immunol, 191 (1): 83-90, 2013.07.Pubmed

Honda R, Cerroni L, Tanikawa A, Ebihara T, Amagai M, Ishiko A
Cutaneous plasmacytosis: Report of 6 cases with or without systemic involvement
J Am Acad Dermatol, 68 (6): 978-985, 2013.06. Pubmed

Veraitch O, Kobayashi T, Imaizumi Y, Akamatsu W, Sasaki T, Yamanaka S, Amagai M, Okano H, Ohyama M
Human induced pluripotent stem cell-derived ectodermal precursor cells contribute to hair follicle morphogenesis in vivo
J Invest Dermatol, 133 (6): 1479-1488, 2013.06. Pubmed

Kubo A, Ishizaki I, Kubo A, Kawasaki H, Nagao K, Ohashi Y, Amagai M
The stratum corneum comprises three layers with distinct metal-ion barrier properties
Sci Rep, 3: 1731, 2013.04. Pubmed

2012

Nagao K, Kobayashi T, Moro K, Ohyama M, Adachi T, Kitashima DY, Ueha S, Horiuchi K, Tanizaki H, Kabashima K, Kubo A, Cho YH, Clausen BE, Matsushima K, Suematsu M, Furtado GC, Lira SA, Farber JM, Udey MC, Amagai M.
Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin.
Nat Immunol 13(8):744-752,2012 Pubmed

Nagao K, Kobayashi T, Ohyama M, Akiyama H, Horiuchi K, Amagai M.
Brief Report: Requirement of TACE/ADAM17 for Hair Follicle Bulge Niche Establishment.
Stem Cells 30(8):1781-1785,2012 Pubmed

Restoration of the intrinsic properties of human dermal papilla in vitro.
Ohyama M, Kobayashi T, Sasaki T, Shimizu A, Amagai M.
J Cell Sci (E-pub), 2012 Pubmed

Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice.
Kawasaki H, Nagao K, Kubo A, Hata T, Shimizu A, Mizuno H, Yamada T, Amagai M.
J Allergy Clin Immunol 129(6):1538-1546,2012 Pubmed

Saleh MA, Ishii K, Yamagami J, Shirakata Y, Hashimoto K, Amagai M.
Pathogenic anti-desmoglein 3 mAbs cloned from a paraneoplastic pemphigus patient by phage display.
J Invest Dermatol ;132(4):1141-1148,2012 Pubmed

Kubo A, Nagao K, Amagai M.
Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases.
J Clin Invest,122(2):440-447,2012 Pubmed

2011

Wada N, Nishifuji K, Yamada T, Kudoh J, Shimizu N, Matsumoto M, Peltonen L, Nagafuchi S, Amagai M.
Aire-dependent thymic expression of desmoglein 3, the autoantigen in pemphigus vulgaris, and its role in T-cell tolerance.
J Invest Dermatol 131(2):410-417,2011 Pubmed

Pathogenic relevance of IgG and IgM antibodies against desmoglein 3 in blister formation in pemphigus vulgaris.
Tsunoda K, Ota T, Saito M, Hata T, Shimizu A, Ishiko A, Yamada T, Nakagawa T, Kowalczyk AP, Amagai M.
Am J Pathol 179(2):795-806,2011 Pubmed

Desmoglein 3-specific CD4+ T cells induce pemphigus vulgaris and interface dermatitis in mice.
Takahashi H, Kouno M, Nagao K, Wada N, Hata T, Nishimoto S, Iwakura Y, Yoshimura A, Yamada T, Kuwana M, Fujii H, Koyasu S, Amagai M.
J Clin Invest 121(9):3677-3688,2011 Pubmed

Saleh MA, Ishii K, Kim YJ, Murakami A, Ishii N, Hashimoto T, Schmidt E, Zillikens D, Shirakata Y, Hashimoto K, Kitajima Y, Amagai M
Development of NC1 and NC2 domains of type VII collagen ELISA for the diagnosis and analysis of the time course of epidermolysis bullosa acquisita patients.
J Dermatol Sci 62(3):169-175,2011 Pubmed

Ouchi T, Kubo A, Yokouchi M, Adachi T, Kobayashi T, Kitashima DY, Fujii H, Clausen BE, Koyasu S, Amagai M, Nagao K.
Langerhans cell antigen capture through tight junctions confers preemptive immunity in experimental staphylococcal scalded skin syndrome.
J Exp Med19;208(13):2607-2613,2011 Pubmed

Matsui T, Miyamoto K, Kubo A, Kawasaki H, Ebihara T, Hata K, Tanahashi S, Ichinose S, Imoto I, Inazawa J, Kudoh J, Amagai M.
SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing.
EMBO Mol 3(6):320-33,2011 Pubmed

Hata T, Nishifuji K, Shimoda K, Sasaki T, Yamada T, Nishikawa T, Koyasu S, Amagai M.
Transgenic rescue of desmoglein 3 null mice with desmoglein 1 to develop a syngeneic mouse model for pemphigus vulgaris. Pubmed
J Dermatol Sci 63(1):33-9, 2011

Wada N, Nishifuji K, Yamada T, Kudoh J, Shimizu N, Matsumoto M, Peltonen L, Nagafuchi S, Amagai M.
Aire-dependent thymic expression of desmoglein 3, the autoantigen in pemphigus vulgaris, and its role in T-cell tolerance.
J Invest Dermatol. 2011 Feb;131(2):410-417,2011.02. Pubmed

2010

Nishifuji K, Shimizu A, Ishiko A, Iwasaki T, Amagai M
Removal of amino-terminal extracellular domains of desmoglein 1 by staphylococcal exfoliative toxin is sufficient to initiate epidermal blister formation.
J Dermatol Sci. 2010 Sep;59(3):184-191,2010.09 Pubmed

Kobayashi T, Iwasaki T, Amagai M, Ohyama M
Canine Follicle Stem Cell Candidates Reside in the Bulge and Share Characteristic Features with Human Bulge Cells
J Invest Drmatol,130(8):1988-95,2010.08 Pubmed

Chan PT, Ohyama B, Nishifuji K, Yoshida K, Ishii K , Hashimoto T, Amagai M.
Immune response towards the amino-terminus of desmoglein 1 prevails across different activity
stages in nonendemic pemphigus foliaceus
Br J Dermatol,162(6):1242-1250,2010.06 Pubmed

Nishifuji K, Shimizu A, Ishiko A, Iwasaki T, Amagai M.
Removal of amino-terminal extracellular domains of desmoglein 1 by staphylococcal exfoliative toxin is sufficient to initiate epidermal blister formation. Pubmed
J Dermatol Sci 59(3):184-191, 2010

2009

Kubo A, Nagao K, Yokouchi M, Sasaki H, Amagai M.
J Exp Med Dec 21;206(13):2937-2946,2009
External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers.Pubmed

Saito H, Shimizu A, Tsunoda K, Amagai M, Ishiko A
Subcellular localization of desmosomal components is different between desmoglein3 knockout mice and pemphigus vulgaris model mice.
J Dermatol Sci 55(2):108-115,2009 Pubmed

Fallon PG, Sasaki T, Sandilands A, Campbell LE, Saunders SP, Mangan NE, Callanan JJ, Kawasaki H, Shiohama A, Kubo A, Sundberg JP, Presland RB, Fleckman P, Shimizu N, Kudoh J, Irvine AD, Amagai M, McLean WH.
A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming.
Nat GenetM 41(5):602-628,2009 Pubmed

Amagai M, Ikeda S, Shimizu H, Iizuka H, Hanada K, Aiba S, Kaneko F, Izaki S, Tamaki K, Ikezawa Z, Takigawa M, Seishima M, Tanaka T, Miyachi Y, Katayama I, Horiguchi Y, Miyagawa S, Furukawa F, Iwatsuki K, Hide M, Tokura Y, Furue M, Hashimoto T, Ihn H, Fujiwara S, Nishikawa T, Ogawa H, Kitajima Y, Hashimoto K
A randomized double-blind trial of intravenous immunoglobulin for pemphigus.
J Am Acad Dermatol 60(4):595-603,2009 Pubmed

Yokouchi M, Saleh MA, Kuroda K, Hachiya T, Stanley JR, Amagai M, Ishii K.
Pathogenic epitopes of autoantibodies in pemphigus reside in the amino-terminal adhesive region of desmogleins which are unmasked by proteolytic processing of prosequence.
J Invest Dermatol 129(9):2156-2166,2009 Pubmed

Takae Y, Nishikawa T, Amagai M.
Pemphigus mouse model as a tool to evaluate various immunosuppressive therapies.
Exp Dermatol 18(3):252-260,2009 Pubmed

Takahashi H, Kuwana M, Amagai M.
A single helper T cell clone is sufficient to commit polyclonal naive B cells to produce pathogenic IgG in experimental pemphigus vulgaris.
J Immunol 182(3):1740-1745,2009 Pubmed

Wang W, Amagai M, Ishiko A.
Desmosome splitting is a primary ultrastructural change in the acantholysis of pemphigus.
J Dermatol Sci 54(1):59-61,2009 Pubmed

Chan PT, Ishiko A, Wada N, Yamamoto N, Amagai M.
Inflammatory plaque with peripheral nodules: a new specific finding of cutaneous polyarteritis nodosa.
J Am Acad Dermatol 60(2):320-325,2009 Pubmed

2008

Kubo A, Yuba-Kubo A, Tsukita S, Tsukita S, Amagai M.
Sentan: a novel specific component of the apical structure of vertebrate motile cilia
Mol Biol Cell 19(12):5338-5346,2008 Pubmed

Takahashi H, Amagai M, Nishikawa T, Fujii Y, Kawakami Y, Kuwana M.
Novel system evaluating in vivo pathogenicity of desmoglein 3-reactive T cell clones using murine pemphigus vulgaris.
J Immunol 15;181(2):1526-1535,2008 Pubmed

Ota T, Aoki-Ota M, Tsunoda K, Nishikawa T, Koyasu S, Amagai M.
Autoreactive B-cell elimination by pathogenic IgG specific for the same antigen: implications for peripheral tolerance.
Int Immunol 20(10):1351-360,2008 Pubmed

Takae Y, Nishikawa T, Amagai M.
Pemphigus mouse model as a tool to evaluate various immunosuppressive therapies.
Exp Dermatol 18(3):252-260,2008 Pubmed

Nagasaka T, Fujii Y, Ishida A, Handa M, Tanikawa A, Amagai M, Nishikawa T.
Evaluating efficacy of plasmapheresis for patients with pemphigus using desmoglein enzyme-linked immunosorbent assay.
Br J Dermatol 158(4):685-690, 2008 Pubmed

2007

Ohyama M, Vogel JC, Amagai M.
Gene ontology analysis of human hair follicle bulge molecular signature Pubmed
J Dermatol Sci 45(2):147-150,2007

2006

Stanley JR, Amagai M.
Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome.
N Engl J Med 355(17):1800-1810,2006 Pubmed

Kawasaki H, Tsunoda K, Hata T, Ishii K, Yamada T, Amagai M.
Synergistic pathogenic effects of combined mouse monoclonal anti-desmoglein 3 IgG antibodies on pemphigus vulgaris blister formation.
J Invest Dermatol 126(12):2621-2630,2006 Pubmed

2005

Ishii K, Harada R, Matsuo I, Shirakata Y, Hashimoto K, Amagai M.
In vitro keratinocyte dissociation assay for evaluation of the pathogenicity of anti-desmoglein 3 IgG autoantibodies in pemphigus vulgaris.
J Invest Dermatol 124(5):939-946,2005 Pubmed

2004

Nagasaka T, Nishifuji K, Ota T, Whittock NV, Amagai M.
Defining the pathogenic involvement of desmoglein 4 in pemphigus and staphylococcal scalded skin syndrome.
J Clin Invest 114(10):1484-492,2004 Pubmed

2003

Ota T, Amagai M, Watanabe M, Nishikawa T.
No involvement of IgG autoantibodies against extracellular domains of desmoglein 2 in paraneoplastic pemphigus or inflammatory bowel diseases.
J Dermatol Sci. 32(2):137-141,2003 Pubmed

Tsunoda K, Ota T, Aoki M, Yamada T, Nagai T, Nakagawa T, Koyasu S, Nishikawa T, Amagai M.
Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3.
J Immunol 170(4):2170-8,2003 Pubmed

Ohyama M, Ota T, Aoki M, Tsunoda K, Harada R, Koyasu S, Nishikawa T, Amagai M.
Suppression of the immune response against exogenous desmoglein 3 in desmoglein 3 knockout mice: an implication for gene therapy.
J Invest Dermatol 120(4):610-615,2003 Pubmed

2002

Tsunoda K, Ota T, Suzuki H, Ohyama M, Nagai T, Nishikawa T, Amagai M, Koyasu S.
Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigus vulgaris.
Eur J Immunol 32(3):627-633,2002 Pubmed

Kobayashi M, Amagai M, Kuroda-Kinoshita K, Hashimoto T, Shirakata Y, Hashimoto K, Nishikawa T.
BP180 ELISA using bacterial recombinant NC16a protein as a diagnostic and monitoring tool for bullous pemphigoid.
J Dermatol Sci 30(3):224-232,2002 Pubmed

Yamaguchi T, Nishifuji K, Sasaki M, Fudaba Y, Aepfelbacher M, Takata T, Ohara M, Komatsuzawa H, Amagai M, Sugai M.
Identification of the Staphylococcus aureus etd pathogenicity island which encodes a novel exfoliative toxin, ETD, and EDIN-B.
Infect Immun 70(10):5835-5845,2002 Pubmed

Hanakawa Y, Schechter NM, Lin C, Garza L, Li H, Yamaguchi T, Fudaba Y, Nishifuji K, Sugai M, Amagai M, Stanley JR.
Molecular mechanisms of blister formation in bullous impetigo and staphylococcal scalded skin syndrome.
J Clin Invest 110(1):53-60.,2002 Pubmed

Ohyama M, Amagai M, Tsunoda K, Ota T, Koyasu S, Hata J, Umezawa A, Nishikawa T.
Immunologic and histopathologic characterization of an active disease mouse model for pemphigus vulgaris.
J Invest Dermatol 118(1):199-204,2002 Pubmed

Amagai M, Yamaguchi T, Hanakawa Y, Nishifuji K, Sugai M, Stanley JR.
Staphylococcal exfoliative toxin B specifically cleaves desmoglein 1.
J Invest Dermatol 118(5):845-850,2002 Pubmed

2001

Sekiguchi M, Futei Y, Fujii Y, Iwasaki T, Nishikawa T, Amagai M.
Dominant autoimmune epitopes recognized by pemphigus antibodies map to the N-terminal adhesive region of desmogleins.
J Immunol 167(9):5439-5448,2001 Pubmed

2000

Amagai M, Matsuyoshi N, Wang ZH, Andl C, Stanley JR.
Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1.
Nat Med 6(11):1275-1277,2000 Pubmed

Wu H, Wang ZH, Yan A, Lyle S, Fakharzadeh S, Wahl JK, Wheelock MJ, Ishikawa H, Uitto J, Amagai M, Stanley JR.
Protection against pemphigus foliaceus by desmoglein 3 in neonates.
N Engl J Med 343(1):31-35,2000 Pubmed

Amagai M, Tsunoda K, Suzuki H, Nishifuji K, Koyasu S, Nishikawa T.
Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus.
J Clin Invest 105(5):625-631,2000 Pubmed

Nishifuji K, Amagai M, Kuwana M, Iwasaki T, Nishikawa T.
Detection of antigen-specific B cells in patients with pemphigus vulgaris by enzyme-linked immunospot assay: requirement of T cell collaboration for autoantibody production.
J Invest Dermatol 114(1) :88-94,2000 Pubmed

Proby CM, Ota T, Suzuki H, Koyasu S, Gamou S, Shimizu N, Wahl JK, Wheelock MJ, Nishikawa T, Amagai M.
Development of chimeric molecules for recognition and targeting of antigen-specific B cells in pemphigus vulgaris.
Br J Dermatol 142(2):321-330,2000 Pubmed

1999

Mahoney MG, Wang Z, Rothenberger K, Koch PJ, Amagai M, Stanley JR.
Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris.
J Clin Invest 103(4):461-468,1999. Pubmed

Proby C, Fujii Y, Owaribe K, Nishikawa T, Amagai M.
Human autoantibodies against HD1/plectin in paraneoplastic pemphigus.
J Invest Dermatol 112(2):153-156,1999 Pubmed

Amagai M, Komai A, Hashimoto T, Shirakata Y, Hashimoto K, Yamada T, Kitajima Y, Ohya K, Iwanami H, Nishikawa T.
Usefulness of enzyme-linked immunosorbent assay using recombinant desmogleins 1 and 3 for serodiagnosis of pemphigus.
Br J Dermato 140(2):351-357,1999 Pubmed

1998

Amagai M, Nishikawa T, Nousari HC, Anhalt GJ, Hashimoto T.
Antibodies against desmoglein 3 (pemphigus vulgaris antigen) are present in sera from patients with paraneoplastic pemphigus and cause acantholysis in vivo in neonatal mice.
J Clin Invest 102(4):775-782,1998 Pubmed

1997

Hashimoto T, Kiyokawa C, Mori O, Miyasato M, Chidgey MA, Garrod DR, Kobayashi Y, Komori K, Ishii K, Amagai M, Nishikawa T.Human desmocollin 1 (Dsc1) is an autoantigen for the subcorneal pustular dermatosis type of IgA pemphigus.
J Invest Dermatol 109(2):127-131,1997 Pubmed

Ishii K, Amagai M, Hall RP, Hashimoto T, Takayanagi A, Gamou S, Shimizu N, Nishikawa T.
Characterization of autoantibodies in pemphigus using antigen-specific enzyme-linked immunosorbent assays with baculovirus-expressed recombinant desmogleins.
J Immunol 159(4):2010-2017,1997 Pubmed

1996

Amagai M, Ishii K, Takayanagi A, Nishikawa T, Shimizu N.
Transport to endoplasmic reticulum by signal peptide, but not proteolytic processing, is required for formation of conformational epitopes of pemphigus vulgaris antigen (Dsg3).
J Invest Dermatol 107(4):539-542,1996 Pubmed

Amagai M, Koch PJ, Nishikawa T, Stanley JR.
J Invest Dermatol 106(2):351-355,1996
Pemphigus vulgaris antigen (desmoglein 3) is localized in the lower epidermis, the site of blister formation in patients. Pubmed

1995

Amagai M, Ishii K, Hashimoto T, Gamou S, Shimizu N, Nishikawa T.
Conformational epitopes of pemphigus antigens (Dsg1 and Dsg3) are calcium dependent and glycosylation independent.
J Invest Dermato 105(2):243-247,1995 Pubmed

Amagai M, Hashimoto T, Green KJ, Shimizu N, Nishikawa T.
Antigen-specific immunoadsorption of pathogenic autoantibodies in pemphigus foliaceus.
J Invest Dermatol 104(6):895-90,1995 Pubmed

1994

Amagai M, Hashimoto T, Shimizu N, Nishikawa T.
Absorption of pathogenic autoantibodies by the extracellular domain of pemphigus vulgaris antigen (Dsg3) produced by baculovirus.
J Clin Invest 94(1):59-67,1994 Pubmed

1993

Tang A, Amagai M, Granger LG, Stanley JR, Udey MC.
Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin.
Nature 361(6407):82-5,1993 Pubmed

1992

Amagai M, Karpati S, Prussick R, Klaus-Kovtun V, Stanley JR
Autoantibodies against the amino-terminal cadherin-like binding domain of pemphigus vulgaris antigen are pathogenic.
J Clin Invest 90(3):919-926,1992 Pubmed

1991

Amagai M, Klaus-Kovtun V, Stanley JR.
Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion.
Cell 67(5):869-877,1991 Pubmed

Amagai M, Elgart GW, Klaus-Kovtun V, Stanley JR.
Southern analysis of the 230-kD bullous pemphigoid antigen gene in normal humans, animals, and patients with junctional epidermolysis bullosa.
J Invest Dermatol 97(2):249-53,1991 Pubmed

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